Personalized therapeutic targeting of specific tumor vulnerabilities
One of the major clinical challenges in these tumors is to identify tumor specific vulnerabilities that can be therapeutically targeted. The lab focuses on understanding the underlying genetic reasons/ mutations that cause such therapeutic vulnerabilities.
In order to do so, the lab focuses on recently developed high-throughput sequencing technologies as well as genome-wide CRISPR-based forward genetic screens. Most importantly, the lab is interested in genomic instability and DNA repair mechanisms that can be leveraged for the development of novel therapies.