DNA circularization as an oncogenic driver of genomic instability in pediatric cancer
In recent years it has become apparent that the genomes of pediatric cancers are more complex than previously anticipated. One phenomenon observed in pediatric cancers is the circularization of DNA.
This circularization not only contributes to genomic plasticity but also seems to drive genomic evolution under therapy more efficiently than other changes. This lets us to believe that DNA circularization might be a major driver of therapy resistance in pediatric cancer patients. We are therefore investigating the causes and consequences of DNA circularization in pediatric tumors.