One of the major clinical challenges in these tumors is to identify tumor specific vulnerabilities that can be therapeutically targeted. The lab focuses on understanding the underlying genetic reasons/ mutations that cause such therapeutic vulnerabilities.
In recent years it has become apparent that the genomes of pediatric cancers are more complex than previously anticipated. One phenomenon observed in pediatric cancers is the circularization of DNA.
Our group of physicians and scientists in the Department of Pediatric Hematology and Oncology at the Charité Universitätsmedizin is particularly interested in understanding how refractory neuroblastoma and rhabdomyosarcoma are formed. Our research is focused on the phenomenon of genomic plasticity and its resultant therapeutically targetable vulnerabilities.
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